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|New Peer Reviewed Publication Shows That BrainStorm's NurOwn® Has a Unique miRNA Signature|
HACKENSACK, N.J. and PETACH TIKVAH, Israel,
The publication shows that NurOwn® (MSC-NTF cells) - mesenchymal stem cells (MSC) induced to secrete neurotrophic factors (NTF) - have both an enhanced secretion of NTFs as well as a distinct miRNA expression profile that distinguishes them from their MSCs of origin. miRNAs are short, non-coding RNAs that regulate gene expression by post transcriptional silencing and have been shown to play critical roles in biological processes. The study shows that BrainStorm's proprietary differentiation process modulates miRNA expression, leading to a unique miRNA signature. These findings may form the basis for the development of sensitive identity release assays for clinical trials, for in vivo cell identification assays and to elucidate MSC-NTF cells' mechanism of action in ALS and other neurodegenerative diseases.
"This study further confirms NurOwn's unique characteristics and underscores our leadership and scientific capability to manufacture the most advanced cell therapies to address neurodegenerative diseases," commented BrainStorm's CEO Chaim Lebovits.
Statements in this announcement other than historical data and information constitute "forward-looking statements" and involve risks and uncertainties that could cause
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